Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.A447S

c.1339G>T

Surrounding Variants

1 paper

NM_004119.3

p.A445_S446insFs

c.1334_1338dup5

1 paper

NM_004119.3

p.L442_S446delFs

c.1326_1336del11

1 paper

NM_004119.3

p.S446insFs

c.1337dupC

3 papers

NM_004119.3

p.S446L

c.1337C>T

1 paper

NM_004119.3

p.A445delFs

c.1333_1334delGC

1 paper

NM_004119.3

p.A445V

c.1334C>T

2 papers

NM_004119.3

p.A445delins

c.1333_1334delinsTT

1 paper

NM_004119.3

p.A445S

c.1333G>T

1 paper

NM_004119.3

p.A445T

c.1333G>A

1 paper

NM_004119.3

p.Q449*

c.1345C>T

1 paper

NM_004119.3

p.Q449K

c.1345C>A

1 paper

NM_004119.3

p.E444fs

c.1330_1331fs