Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_004119.3

p.P439L

c.1316C>T

Surrounding Variants

1 paper

NM_004119.3

p.Q440*

c.1318C>T

1 paper

NM_004119.3

p.K438I

c.1313A>T

1 paper

NM_004119.3

p.V441M

c.1321G>A

1 paper

NM_004119.3

p.V441A

c.1322T>C

1 paper

NM_004119.3

p.R437K

c.1310G>A

1 paper

NM_004119.3

p.R437Splc

c.1310-1G>T

1 paper

NM_004119.3

p.R437Splc

c.1310-1G>A

1 paper

NM_004119.3

p.L442F

c.1324C>T

21 papers

NM_004119.3

p.R437Splc

c.1310-3T>C

1 paper

NM_004119.3

p.L442P

c.1325T>C

2 papers

NM_004119.3

p.A443T

c.1327G>A

1 paper

NM_004119.3

p.A443V

c.1328C>T