Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.T242S

c.724A>T

Surrounding Variants

1 paper

NM_004119.3

p.T242S

c.725C>G

1 paper

NM_004119.3

p.R243K

c.728G>A

2 papers

NM_004119.3

p.E240K

c.718G>A

1 paper

NM_004119.3

p.F245_T246ins5

c.733_737ins15

1 paper

NM_004119.3

p.F245L

c.733T>C

1 paper

NM_004119.3

p.R239G

c.715A>G

1 paper

NM_004119.3

p.G238A

c.713G>C

1 paper

NM_004119.3

p.G238D

c.713G>A

1 paper

NM_004119.3

p.F245L

c.735C>G

2 papers

NM_004119.3

p.F245L

c.735C>A

1 paper

NM_004119.3

p.T246P

c.736A>C

1 paper

NM_004119.3

p.T246I

c.737C>T