Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.F225V

c.673T>G

Surrounding Variants

1 paper

NM_004119.3

p.L224_F225insFs

c.672_673insA

1 paper

NM_004119.3

p.F225L

c.673T>C

1 paper

NM_004119.3

p.F225C

c.674T>G

1 paper

NM_004119.3

p.F225S

c.674T>C

1 paper

NM_004119.3

p.F225L

c.675T>G

1 paper

NM_004119.3

p.F225L

c.675T>A

1 paper

NM_004119.3

p.G226W

c.676G>T

1 paper

NM_004119.3

p.K215_F225del11

c.643_674del33

1 paper

NM_004119.3

p.K215_H222insFs

c.644_665dup22

58 papers

NM_004119.3

p.T227M

c.680C>T

1 paper

NM_004119.3

p.L221L

c.663T>A

1 paper

NM_004119.3

p.L221insFs

c.661dupC