Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.L221I

c.661C>A

Surrounding Variants

1 paper

NM_004119.3

p.L221insFs

c.661dupC

1 paper

NM_004119.3

p.V220fs

c.658_659fs

1 paper

NM_004119.3

p.V220G

c.659T>G

1 paper

NM_004119.3

p.L221L

c.663T>A

1 paper

NM_004119.3

p.K219delFs

c.657delT

1 paper

NM_004119.3

p.K215_H222insFs

c.644_665dup22

1 paper

NM_004119.3

p.K219R

c.656A>G

1 paper

NM_004119.3

p.E218D

c.654A>T

3 papers

NM_004119.3

p.E218G

c.653A>G

1 paper

NM_004119.3

p.E218_K219insC

c.652_656ins3

1 paper

NM_004119.3

p.E217V

c.650A>T

1 paper

NM_004119.3

p.E217ins3

c.650_651ins9