Varaico: Literature-Extracted Genetic Variants

FLT4

789 papers

RefSeq Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. M...

Pfam Domains

VEGFR1-3_N_Ig-likeaa 28–142UCSCVEGFR1-3, N-terminal Ig-like domain

Ig_2aa 137–224UCSCImmunoglobulin domain

VEGFR-1-like_Ig-likeaa 143–224UCSCVascular endothelial growth factor receptor 1-like, Ig-like domain

Ig_3aa 231–314UCSCImmunoglobulin domain

Ig_VEGFR-1-like_5thaa 419–553UCSCVEGFR-1-like, immunoglobulin-like domain

I-setaa 678–765UCSCImmunoglobulin I-set domain

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 4

HGNC Alias Symbols

VEGFR3; PCL; VEGFR-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_182925.5

p.R1354H

c.4061G>A

Surrounding Variants

1 paper

NM_182925.5

p.R1354R

c.4062C>T

3 papers

NM_182925.5

p.V1355M

c.4063G>A

1 paper

NM_182925.5

p.F1357L

c.4069T>C

1 paper

NM_182925.5

p.F1357L

c.4071C>G

1 paper

NM_182925.5

p.F1357L

c.4071C>A

1 paper

NM_182925.5

p.H1348Y

c.4042C>T

1 paper

NM_182925.5

p.D1347_H1348delins

c.4041_4042delinsTT

1 paper

NM_182925.5

p.N1361H

c.4081A>C

1 paper

NM_182925.5

p.Y1363F

c.4088A>T

1 paper

NM_182925.5

p.E1345*

c.4033G>T

1 paper

NM_182925.5

p.E1345K

c.4033G>A

1 paper

NM_182925.5

p.P1343Q

c.4028C>A