Varaico: Literature-Extracted Genetic Variants

FLT4

789 papers

RefSeq Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. M...

Pfam Domains

VEGFR1-3_N_Ig-likeaa 28–142UCSCVEGFR1-3, N-terminal Ig-like domain

Ig_2aa 137–224UCSCImmunoglobulin domain

VEGFR-1-like_Ig-likeaa 143–224UCSCVascular endothelial growth factor receptor 1-like, Ig-like domain

Ig_3aa 231–314UCSCImmunoglobulin domain

Ig_VEGFR-1-like_5thaa 419–553UCSCVEGFR-1-like, immunoglobulin-like domain

I-setaa 678–765UCSCImmunoglobulin I-set domain

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 4

HGNC Alias Symbols

VEGFR3; PCL; VEGFR-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_182925.5

p.Y1333F

c.3998A>T

Surrounding Variants

14 papers

NM_182925.5

p.E1336K

c.4006G>A

1 paper

NM_182925.5

p.Q1330E

c.3988C>G

1 paper

NM_182925.5

p.Y1337F

c.4010A>T

1 paper

NM_182925.5

p.Y1337fs

c.4009_4010fs

3 papers

NM_182925.5

p.G1329S

c.3985G>A

1 paper

NM_182925.5

p.G1328V

c.3983G>T

1 paper

NM_182925.5

p.E1339*

c.4015G>T

1 paper

NM_182925.5

p.R1327Q

c.3980G>A

1 paper

NM_182925.5

p.A1326fs

c.3976_3977fs

1 paper

NM_182925.5

p.A1326delFs

c.3976delC

2 papers

NM_182925.5

p.S1341L

c.4022C>T

1 paper

NM_182925.5

p.S1341S

c.4023G>A