Varaico: Literature-Extracted Genetic Variants

FLT4

789 papers

RefSeq Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. M...

Pfam Domains

VEGFR1-3_N_Ig-likeaa 28–142UCSCVEGFR1-3, N-terminal Ig-like domain

Ig_2aa 137–224UCSCImmunoglobulin domain

VEGFR-1-like_Ig-likeaa 143–224UCSCVascular endothelial growth factor receptor 1-like, Ig-like domain

Ig_3aa 231–314UCSCImmunoglobulin domain

Ig_VEGFR-1-like_5thaa 419–553UCSCVEGFR-1-like, immunoglobulin-like domain

I-setaa 678–765UCSCImmunoglobulin I-set domain

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 4

HGNC Alias Symbols

VEGFR3; PCL; VEGFR-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

29 papers

NM_182925.5

p.P1137L

c.3410C>T

Surrounding Variants

1 paper

NM_182925.5

p.P1137S

c.3409C>T

1 paper

NM_182925.5

p.P1137T

c.3409C>A

1 paper

NM_182925.5

p.E1138G

c.3413A>G

1 paper

NM_182925.5

p.R1135R

c.3405G>A

1 paper

NM_182925.5

p.A1143T

c.3427G>A

2 papers

NM_182925.5

p.G1131D

c.3392G>A

4 papers

NM_182925.5

p.G1131R

c.3391G>C

6 papers

NM_182925.5

p.G1131S

c.3391G>A

1 paper

NM_182925.5

p.D1130D

c.3390C>T

1 paper

NM_182925.5

p.D1130delFs

c.3388_3389delTC

1 paper

NM_182925.5

p.D1130fs

c.3388_3389fs

1 paper

NM_182925.5

p.R1127P

c.3380G>C