Varaico: Literature-Extracted Genetic Variants

FLT4

789 papers

RefSeq Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. M...

Pfam Domains

VEGFR1-3_N_Ig-likeaa 28–142UCSCVEGFR1-3, N-terminal Ig-like domain

Ig_2aa 137–224UCSCImmunoglobulin domain

VEGFR-1-like_Ig-likeaa 143–224UCSCVascular endothelial growth factor receptor 1-like, Ig-like domain

Ig_3aa 231–314UCSCImmunoglobulin domain

Ig_VEGFR-1-like_5thaa 419–553UCSCVEGFR-1-like, immunoglobulin-like domain

I-setaa 678–765UCSCImmunoglobulin I-set domain

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 4

HGNC Alias Symbols

VEGFR3; PCL; VEGFR-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182925.5

p.D1049E

c.3147C>A

Surrounding Variants

1 paper

NM_182925.5

p.V1050M

c.3148G>A

4 papers

NM_182925.5

p.D1049N

c.3145G>A

1 paper

NM_182925.5

p.V1051L

c.3151G>T

1 paper

NM_182925.5

p.S1048I

c.3143G>T

1 paper

NM_182925.5

p.V1051L

c.3151G>C

2 papers

NM_182925.5

p.V1051M

c.3151G>A

1 paper

NM_182925.5

p.V1051fs

c.3151_3152fs

1 paper

NM_182925.5

p.E1047G

c.3140A>G

2 papers

NM_182925.5

p.S1046L

c.3137C>T

9 papers

NM_182925.5

p.I1053F

c.3157A>T

1 paper

NM_182925.5

p.L1045P

c.3134T>C

2 papers

NM_182925.5

p.C1054S

c.3160T>A