Varaico: Literature-Extracted Genetic Variants

FLT4

789 papers

RefSeq Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. M...

Pfam Domains

VEGFR1-3_N_Ig-likeaa 28–142UCSCVEGFR1-3, N-terminal Ig-like domain

Ig_2aa 137–224UCSCImmunoglobulin domain

VEGFR-1-like_Ig-likeaa 143–224UCSCVascular endothelial growth factor receptor 1-like, Ig-like domain

Ig_3aa 231–314UCSCImmunoglobulin domain

Ig_VEGFR-1-like_5thaa 419–553UCSCVEGFR-1-like, immunoglobulin-like domain

I-setaa 678–765UCSCImmunoglobulin I-set domain

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 4

HGNC Alias Symbols

VEGFR3; PCL; VEGFR-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182925.5

p.S953F

c.2858C>T

Surrounding Variants

1 paper

NM_182925.5

p.K952delFs

c.2854_2855delTT

21 papers

NM_182925.5

p.P954S

c.2860C>T

1 paper

NM_182925.5

p.E951del1

c.2851_2852delCTC

1 paper

NM_182925.5

p.E955*

c.2863G>T

1 paper

NM_182925.5

p.E951D

c.2853G>T

1 paper

NM_182925.5

p.E951fs

c.2851_2852fs

1 paper

NM_182925.5

p.E955Q

c.2863G>C

1 paper

NM_182925.5

p.E951D

c.2853G>C

1 paper

NM_182925.5

p.R959delFs

c.2875delG

2 papers

NM_182925.5

p.R961G

c.2881C>G

3 papers

NM_182925.5

p.L966F

c.2896C>T

1 paper

NM_182925.5

p.R971fs

c.2911_2912fs