Varaico: Literature-Extracted Genetic Variants

Gene:FRAT1

FRAT1

28 papers

RefSeq Summary

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It...

Pfam Domains

GSK-3_bindaa 1–239UCSCGlycogen synthase kinase-3 binding

Gene Aliases

HGNC Name

FRAT regulator of Wnt signaling pathway 1

HGNC Previous Names

FRAT regulator of WNT signaling pathway 1; frequently rearranged in advanced T-cell lymphomas; frequently rearranged in advanced T-cell lymphomas 1; FRAT1, WNT signaling pathway regulator

Papers
RefSeq ID
Protein change
DNA change
1–12 of 28 variants
1 paper
NM_005479.4
p.R4L
c.11G>T
1 paper
NM_005479.4
p.E18G
c.53A>G
1 paper
NM_005479.4
p.V40L
c.118G>C
1 paper
NM_005479.4
p.V40L
c.118G>T
1 paper
NM_005479.4
p.Q57K
c.169C>A
1 paper
NM_005479.4
p.Q57*
c.169C>T
1 paper
NM_005479.4
p.H58D
c.172C>G
1 paper
NM_005479.4
p.S62L
c.185C>T
1 paper
NM_005479.4
p.A80S
c.238G>T
1 paper
NM_005479.4
p.K85R
c.254A>G
1 paper
NM_005479.4
p.K85M
c.254A>T
1 paper
NM_005479.4
p.V130M
c.388G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."