Varaico: Literature-Extracted Genetic Variants

Gene:FYB1
Variant:p.Y462F

FYB1

46 papers

RefSeq Summary

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interle...

Pfam Domains

SH3_2aa 515–570UCSCVariant SH3 domain
hSH3aa 695–783UCSCHelically-extended SH3 domain

Gene Aliases

HGNC Name

FYN binding protein 1

HGNC Alias Symbols

SLAP-130; FYB-120/130

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001465.6
p.Y462F
c.1385A>T
Surrounding Variants
1 paper
NM_001465.6
p.Y462*
c.1386T>G
1 paper
NM_001465.6
p.Y462*
c.1386T>A
2 papers
NM_001465.6
p.Y462delFs
c.1385_1386delAT
1 paper
NM_001465.6
p.K505_L506Splc
c.1515+6G>A
1 paper
NM_001465.6
p.N435insFs
c.1305dupT
1 paper
NM_001465.6
p.Y559F
c.1676A>T
2 papers
NM_001465.6
p.Y571F
c.1712A>T
1 paper
NM_001465.6
p.Y595F
c.1784A>T
1 paper
NM_001465.6
p.E600Q
c.1798G>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."