guided entry of tail-anchored proteins factor 1

tryptophan rich basic protein

Guided entry of tail-anchored proteins factor 1

Congenital heart disease 5 protein

Tail-anchored protein insertion receptor WRB

Tryptophan-rich basic protein

This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017].

Varaico: Literature-Extracted Genetic Variants

GET1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol