gamma-glutamyltransferase 5

GGTLA1

GGT-REL

gamma-glutamyltransferase-like activity 1

Glutathione hydrolase 5 proenzyme

Gamma-glutamyl transpeptidase-related enzyme

Gamma-glutamyltransferase 5

Gamma-glutamyltransferase-like activity 1

Gamma-glutamyltranspeptidase 5

Leukotriene-C4 hydrolase

Glutathione hydrolase 5 heavy chain

Glutathione hydrolase 5 light chain

GGT-rel

GGT 5

This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].

Varaico: Literature-Extracted Genetic Variants

GGT5

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol