glutamate ionotropic receptor AMPA type subunit 4

GLUR4

GluA4

GLURD

GluR-4

GluR-D

GLUR4C

glutamate receptor, ionotrophic, AMPA 4

Glutamate receptor 4

AMPA-selective glutamate receptor 4

Glutamate receptor ionotropic, AMPA 4

GluR4

Ligated ion channel L-glutamate- and glycine-binding site

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

GRIA4

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol