Varaico: Literature-Extracted Genetic Variants

GRK2

235 papers

RefSeq Summary

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates incl...

Pfam Domains

RGSaa 54–174UCSCRegulator of G protein signaling domain

Pkinaseaa 191–453UCSCProtein kinase domain

PHaa 559–652UCSCPH domain

Gene Aliases

HGNC Name

G protein-coupled receptor kinase 2

HGNC Previous Symbol

ADRBK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001619.5

p.Q285K

c.853C>A

Surrounding Variants

1 paper

NM_001619.5

p.S284_Q285delFs

c.852_855del4

2 papers

NM_001619.5

p.S284A

c.850T>G

1 paper

NM_001619.5

p.D278A

c.833A>C

1 paper

NM_001619.5

p.A292P

c.874G>C

1 paper

NM_001619.5

p.R295L

c.884G>T

1 paper

NM_001619.5

p.I301I

c.903C>T

1 paper

NM_001619.5

p.M308I

c.924G>C

1 paper

NM_001619.5

p.R311H

c.932G>A

1 paper

NM_001619.5

p.Y315_R316insFs

c.945_946insC

1 paper

NM_001619.5

p.D317A

c.950A>C

1 paper

NM_001619.5

p.L318insFs

c.952_953insA

1 paper

NM_001619.5

p.S268T

c.803G>C