Varaico: Literature-Extracted Genetic Variants

Gene:GRK4
Variant:p.I223K

GRK4

160 papers

RefSeq Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms ...

Pfam Domains

RGSaa 52–171UCSCRegulator of G protein signaling domain
Pkinaseaa 187–449UCSCProtein kinase domain

Gene Aliases

HGNC Name

G protein-coupled receptor kinase 4

HGNC Previous Symbol

GPRK2L

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_182982.3
p.I223K
c.668T>A
Surrounding Variants
1 paper
NM_182982.3
p.R222fs
c.664_665fs
2 papers
NM_182982.3
p.R222fs
c.664_665fs
1 paper
NM_182982.3
p.K220E
c.658A>G
1 paper
NM_182982.3
p.R222insFs
c.664dupA
1 paper
NM_182982.3
p.Q219fs
c.655_656fs
1 paper
NM_182982.3
p.R222delFs
c.664delA
1 paper
NM_182982.3
p.C215R
c.643T>C
NM_001004056.2
p.C183R
c.547T>C
1 paper
NM_182982.3
p.G210E
c.629G>A
1 paper
NM_182982.3
p.K211delFs
c.632delA
5 papers
NM_182982.3
p.V247I
c.739G>A
1 paper
NM_182982.3
p.V247_V248Splc
c.741+1G>A
1 paper
NM_182982.3
p.V192A
c.575T>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."