Varaico: Literature-Extracted Genetic Variants

Gene:GRK4
Variant:p.G437R

GRK4

160 papers

RefSeq Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms ...

Pfam Domains

RGSaa 52–171UCSCRegulator of G protein signaling domain
Pkinaseaa 187–449UCSCProtein kinase domain

Gene Aliases

HGNC Name

G protein-coupled receptor kinase 4

HGNC Previous Symbol

GPRK2L

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_182982.3
p.G437R
c.1309G>C
Surrounding Variants
1 paper
NM_182982.3
p.G437S
c.1309G>A
1 paper
NM_182982.3
p.A440V
c.1319C>T
1 paper
NM_182982.3
p.A441T
c.1321G>A
1 paper
NM_182982.3
p.K444K
c.1332G>A
4 papers
NM_182982.3
p.L425P
c.1274T>C
1 paper
NM_182982.3
p.F454S
c.1361T>C
1 paper
NM_182982.3
p.L457P
c.1370T>C
1 paper
NM_182982.3
p.P470L
c.1409C>T
1 paper
NM_182982.3
p.H471Y
c.1411C>T
1 paper
NM_182982.3
p.V473I
c.1417G>A
1 paper
NM_182982.3
p.D477A
c.1430A>C
12 papers
NM_182982.3
p.V486A
c.1457T>C
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