Varaico: Literature-Extracted Genetic Variants

Gene:GRK5
Variant:p.R399H

GRK5

179 papers

RefSeq Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms ...

Pfam Domains

RGSaa 52–170UCSCRegulator of G protein signaling domain
Pkinaseaa 186–448UCSCProtein kinase domain

Gene Aliases

HGNC Name

G protein-coupled receptor kinase 5

HGNC Previous Symbol

GPRK5

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005308.3
p.R399H
c.1196G>A
Surrounding Variants
1 paper
NM_005308.3
p.R399C
c.1195C>T
3 papers
NM_005308.3
p.K389T
c.1166A>C
1 paper
NM_005308.3
p.R388C
c.1162C>T
1 paper
NM_005308.3
p.R386R
c.1158C>T
1 paper
NM_005308.3
p.E414K
c.1240G>A
1 paper
NM_005308.3
p.G370S
c.1108G>A
1 paper
NM_005308.3
p.P366P
c.1098C>T
1 paper
NM_005308.3
p.Y362Y
c.1086C>T
1 paper
NM_005308.3
p.V346M
c.1036G>A
1 paper
NM_005308.3
p.R345R
c.1035G>T
2 papers
NM_005308.3
p.R345Q
c.1034G>A
1 paper
NM_005308.3
p.L330P
c.989T>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."