Varaico: Literature-Extracted Genetic Variants

Gene:GRK6
Variant:p.R221L

GRK6

93 papers

RefSeq Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms ...

Pfam Domains

RGSaa 52–170UCSCRegulator of G protein signaling domain
Pkinaseaa 186–448UCSCProtein kinase domain

Gene Aliases

HGNC Name

G protein-coupled receptor kinase 6

HGNC Previous Symbol

GPRK6

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001004106.3
p.R221L
c.662G>T
Surrounding Variants
1 paper
NM_001004106.3
p.K216R
c.647A>G
1 paper
NM_001004106.3
p.K216M
c.647A>T
2 papers
NM_001004106.3
p.K215R
c.644A>G
1 paper
NM_001004106.3
p.K215M
c.644A>T
1 paper
NM_001004106.3
p.A229A
c.687C>A
1 paper
NM_001004106.3
p.Q236Q
c.708G>A
1 paper
NM_001004106.3
p.Q204E
c.610C>G
1 paper
NM_001004106.3
p.V246_V247Splc
c.738+1G>A
2 papers
NM_001004106.3
p.A252V
c.755C>T
2 papers
NM_001004106.3
p.A258T
c.772G>A
1 paper
NM_001004106.3
p.G269S
c.805G>A
1 paper
NM_001004106.3
p.F167L
c.501C>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."