Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

1–12 of 356 variants

11 papers

NM_001278064.2

p.S993P

c.2977T>C

10 papers

NM_001278064.2

p.P729T

c.2185C>A

8 papers

NM_001278064.2

p.Y792C

c.2375A>G

7 papers

NM_001278064.2

p.L454F

c.1360C>T

7 papers

NM_001278064.2

p.G884E

c.2651G>A

5 papers

NM_001278064.2

p.Y262C

c.785A>G

5 papers

NM_001278064.2

p.T548M

c.1643C>T

5 papers

NM_001278064.2

p.G884_N885del1

c.2652_2654delGAA

5 papers

NM_001278064.2

p.N885del1

c.2653_2654delAAT

5 papers

NM_001278064.2

p.N887Splc

c.2660+2T>G

5 papers

NM_001278064.2

p.G1056fs

c.3166_3167fs

5 papers

NM_001278064.2

p.P1069L

c.3206C>T