Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.L253P

c.758T>C

Surrounding Variants

1 paper

NM_001278064.2

p.L253H

c.758T>A

1 paper

NM_001278064.2

p.C254R

c.760T>C

3 papers

NM_001278064.2

p.I255N

c.764T>A

1 paper

NM_001278064.2

p.I255T

c.764T>C

1 paper

NM_001278064.2

p.I255I

c.765C>A

1 paper

NM_001278064.2

p.A256T

c.766G>A

1 paper

NM_001278064.2

p.A256A

c.768C>G

1 paper

NM_001278064.2

p.S258F

c.773C>T

1 paper

NM_001278064.2

p.K260I

c.779A>T

2 papers

NM_001278064.2

p.K245*

c.733A>T

5 papers

NM_001278064.2

p.Y262C

c.785A>G

4 papers

NM_001278064.2

p.G240R

c.718G>A