Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.G293S

c.877G>A

Surrounding Variants

1 paper

NM_001278064.2

p.E292D

c.876A>C

1 paper

NM_001278064.2

p.E292D

c.876A>T

1 paper

NM_001278064.2

p.G293A

c.878G>C

1 paper

NM_001278064.2

p.E292A

c.875A>C

1 paper

NM_001278064.2

p.C289*

c.867C>A

1 paper

NM_001278064.2

p.R297R

c.889C>A

4 papers

NM_001278064.2

p.R297*

c.889C>T

1 paper

NM_001278064.2

p.L299P

c.896T>C

1 paper

NM_001278064.2

p.R285K

c.854G>A

1 paper

NM_001278064.2

p.A302V

c.905C>T

1 paper

NM_001278064.2

p.P282H

c.845C>A

2 papers

NM_001278064.2

p.R305C

c.913C>T