Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.K449Q

c.1345A>C

Surrounding Variants

2 papers

NM_001278064.2

p.D446N

c.1336G>A

7 papers

NM_001278064.2

p.L454F

c.1360C>T

1 paper

NM_001278064.2

p.A441D

c.1322C>A

4 papers

NM_001278064.2

p.S458A

c.1372T>G

1 paper

NM_001278064.2

p.V436M

c.1306G>A

1 paper

NM_001278064.2

p.H435H

c.1305C>T

1 paper

NM_001278064.2

p.G464R

c.1390G>A

1 paper

NM_001278064.2

p.G464R

c.1390G>C

1 paper

NM_001278064.2

p.E465A

c.1394A>C

1 paper

NM_001278064.2

p.K472N

c.1416A>C

1 paper

NM_001278064.2

p.K472N

c.1416A>T

1 paper

NM_001278064.2

p.D474G

c.1421A>G