Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_001278064.2

p.T548M

c.1643C>T

Surrounding Variants

1 paper

NM_001278064.2

p.C544Y

c.1631G>A

1 paper

NM_001278064.2

p.K534_V535Splc

c.1603-1G>A

3 papers

NM_001278064.2

p.K563N

c.1689A>C

3 papers

NM_001278064.2

p.K563N

c.1689A>T

1 paper

NM_001278064.2

p.C565Y

c.1694G>A

1 paper

NM_001278064.2

p.N572delFs

c.1715delA

1 paper

NM_001278064.2

p.A573E

c.1718C>A

4 papers

NM_001278064.2

p.L575V

c.1723C>G