Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.R628L

c.1883G>T

Surrounding Variants

1 paper

NM_001278064.2

p.R628Q

c.1883G>A

1 paper

NM_001278064.2

p.E629_I634del0

c.1886_1900del15

1 paper

NM_001278064.2

p.C631C

c.1893C>T

3 papers

NM_001278064.2

p.Y632H

c.1894T>C

1 paper

NM_001278064.2

p.A636G

c.1907C>G

1 paper

NM_001278064.2

p.T620A

c.1858A>G

1 paper

NM_001278064.2

p.D619G

c.1856A>G

1 paper

NM_001278064.2

p.G637A

c.1910G>C

1 paper

NM_001278064.2

p.R618Q

c.1853G>A

1 paper

NM_001278064.2

p.Y617H

c.1849T>C

3 papers

NM_001278064.2

p.I604M

c.1812C>G

3 papers

NM_001278064.2

p.L602M

c.1804C>A