Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.Y658H

c.1972T>C

Surrounding Variants

1 paper

NM_001278064.2

p.Y658F

c.1973A>T

1 paper

NM_001278064.2

p.A669T

c.2005G>A

1 paper

NM_001278064.2

p.Y672F

c.2015A>T

1 paper

NM_001278064.2

p.V676M

c.2026G>A

1 paper

NM_001278064.2

p.G637A

c.1910G>C

1 paper

NM_001278064.2

p.A636G

c.1907C>G

1 paper

NM_001278064.2

p.R681S

c.2041C>A

2 papers

NM_001278064.2

p.R681H

c.2042G>A

4 papers

NM_001278064.2

p.A683E

c.2048C>A

4 papers

NM_001278064.2

p.R684C

c.2050C>T

3 papers

NM_001278064.2

p.Y632H

c.1894T>C

1 paper

NM_001278064.2

p.C631C

c.1893C>T