Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.I725F

c.2173A>T

Surrounding Variants

1 paper

NM_001278064.2

p.E728G

c.2183A>G

10 papers

NM_001278064.2

p.P729T

c.2185C>A

3 papers

NM_001278064.2

p.T719P

c.2155A>C

1 paper

NM_001278064.2

p.A705S

c.2113G>T

1 paper

NM_001278064.2

p.S702R

c.2106T>A

1 paper

NM_001278064.2

p.S702R

c.2106T>G

1 paper

NM_001278064.2

p.S702T

c.2105G>C

1 paper

NM_001278064.2

p.S702R

c.2104A>C

1 paper

NM_001278064.2

p.S749T

c.2246G>C

1 paper

NM_001278064.2

p.F700C

c.2099T>G

2 papers

NM_001278064.2

p.P698R

c.2093C>G

1 paper

NM_001278064.2

p.K697M

c.2090A>T