Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.T790delFs

c.2368_2369delAC

Surrounding Variants

1 paper

NM_001278064.2

p.T790fs

c.2368_2369fs

8 papers

NM_001278064.2

p.Y792C

c.2375A>G

2 papers

NM_001278064.2

p.E783Q

c.2347G>C

1 paper

NM_001278064.2

p.N782I

c.2345A>T

2 papers

NM_001278064.2

p.F781S

c.2342T>C

1 paper

NM_001278064.2

p.N780N

c.2340C>T

1 paper

NM_001278064.2

p.A779T

c.2335G>A

1 paper

NM_001278064.2

p.V802M

c.2404G>A

1 paper

NM_001278064.2

p.R775C

c.2323C>T

1 paper

NM_001278064.2

p.F806S

c.2417T>C

1 paper

NM_001278064.2

p.Y770F

c.2309A>T

1 paper

NM_001278064.2

p.Y769F

c.2306A>T