Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.I812F

c.2434A>T

Surrounding Variants

1 paper

NM_001278064.2

p.C816F

c.2447G>T

1 paper

NM_001278064.2

p.F806S

c.2417T>C

1 paper

NM_001278064.2

p.A818S

c.2452G>T

1 paper

NM_001278064.2

p.V819L

c.2455G>T

1 paper

NM_001278064.2

p.V802M

c.2404G>A

3 papers

NM_001278064.2

p.T824R

c.2471C>G

1 paper

NM_001278064.2

p.V825M

c.2473G>A

1 paper

NM_001278064.2

p.A826S

c.2476G>T

8 papers

NM_001278064.2

p.Y792C

c.2375A>G

1 paper

NM_001278064.2

p.T790fs

c.2368_2369fs

1 paper

NM_001278064.2

p.T790delFs

c.2368_2369delAC

1 paper

NM_001278064.2

p.M835I

c.2505G>C