Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_001278064.2

p.N885del1

c.2653_2654delAAT

Surrounding Variants

7 papers

NM_001278064.2

p.G884E

c.2651G>A

5 papers

NM_001278064.2

p.G884_N885del1

c.2652_2654delGAA

5 papers

NM_001278064.2

p.N887Splc

c.2660+2T>G

1 paper

NM_001278064.2

p.K880N

c.2640G>C

1 paper

NM_001278064.2

p.K880N

c.2640G>T

1 paper

NM_001278064.2

p.R877Q

c.2630G>A

1 paper

NM_001278064.2

p.N874S

c.2621A>G

1 paper

NM_001278064.2

p.R868H

c.2603G>A

1 paper

NM_001278064.2

p.C867S

c.2600G>C

1 paper

NM_001278064.2

p.C867S

c.2599T>A

2 papers

NM_001278064.2

p.G861S

c.2581G>A

1 paper

NM_001278064.2

p.T852N

c.2555C>A