Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.S888C

c.2663C>G

Surrounding Variants

1 paper

NM_001278064.2

p.K891delFs

c.2673delG

1 paper

NM_001278064.2

p.S892Y

c.2675C>A

1 paper

NM_001278064.2

p.N887Splc

c.2661-19A>G

1 paper

NM_001278064.2

p.G899G

c.2697T>G

1 paper

NM_001278064.2

p.K905T

c.2714A>C

1 paper

NM_001278064.2

p.V917M

c.2749G>A

1 paper

NM_001278064.2

p.T919I

c.2756C>T

1 paper

NM_001278064.2

p.N920D

c.2758A>G

4 papers

NM_001278064.2

p.V929I

c.2785G>A

1 paper

NM_001278064.2

p.K931K

c.2793G>A

1 paper

NM_001278064.2

p.T953A

c.2857A>G

1 paper

NM_001278064.2

p.Y955*

c.2865C>A