Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.S973N

c.2918G>A

Surrounding Variants

3 papers

NM_001278064.2

p.P970L

c.2909C>T

2 papers

NM_001278064.2

p.R981C

c.2941C>T

1 paper

NM_001278064.2

p.V982M

c.2944G>A

1 paper

NM_001278064.2

p.E961_D962del1

c.2883_2885delGGA

1 paper

NM_001278064.2

p.P989L

c.2966C>T

1 paper

NM_001278064.2

p.V957delFs

c.2870delT

1 paper

NM_001278064.2

p.V957fs

c.2869_2870fs

1 paper

NM_001278064.2

p.Y955*

c.2865C>A

1 paper

NM_001278064.2

p.Y955*

c.2865C>G

1 paper

NM_001278064.2

p.L991L

c.2971C>T

1 paper

NM_001278064.2

p.S993delFs

c.2977delT

11 papers

NM_001278064.2

p.S993P

c.2977T>C