Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.V1051L

c.3151G>T

Surrounding Variants

1 paper

NM_001278064.2

p.V1051L

c.3151G>C

1 paper

NM_001278064.2

p.A1050V

c.3149C>T

1 paper

NM_001278064.2

p.G1054D

c.3161G>A

2 papers

NM_001278064.2

p.P1055insFs

c.3165dupC

1 paper

NM_001278064.2

p.G1056R

c.3166G>C

5 papers

NM_001278064.2

p.G1056fs

c.3166_3167fs

1 paper

NM_001278064.2

p.G1056G

c.3168T>G

1 paper

NM_001278064.2

p.A1044T

c.3130G>A

1 paper

NM_001278064.2

p.N1040delFs

c.3120delC

2 papers

NM_001278064.2

p.R1063P

c.3188G>C

2 papers

NM_001278064.2

p.G1036V

c.3107G>T

1 paper

NM_001278064.2

p.P1068_P1070ins1

c.3204_3209dup6