Varaico: Literature-Extracted Genetic Variants

GRM1

347 papers

RefSeq Summary

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ...

Pfam Domains

ANF_receptoraa 77–487UCSCReceptor family ligand binding region

NCD3Gaa 519–571UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 586–834UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1144–1194UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 1

HGNC Alias Symbols

GPRC1A; mGlu1; MGLUR1; PPP1R85

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001278064.2

p.D1098_D1099del0

c.3292_3297del6

Surrounding Variants

1 paper

NM_001278064.2

p.D1095del1

c.3283_3285delGAC

1 paper

NM_001278064.2

p.L1089P

c.3266T>C

1 paper

NM_001278064.2

p.E1087Q

c.3259G>C

1 paper

NM_001278064.2

p.P1079L

c.3236C>T

1 paper

NM_001278064.2

p.P1079S

c.3235C>T

1 paper

NM_001278064.2

p.V1110E

c.3329T>A

1 paper

NM_001278064.2

p.E1112Q

c.3334G>C

3 papers

NM_001278064.2

p.P1072A

c.3214C>G

3 papers

NM_001278064.2

p.P1071P

c.3213T>G

1 paper

NM_001278064.2

p.P1071S

c.3211C>T

1 paper

NM_001278064.2

p.P1070L

c.3209C>T

5 papers

NM_001278064.2

p.P1069L

c.3206C>T