Varaico: Literature-Extracted Genetic Variants

GRM2

124 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 60–460UCSCReceptor family ligand binding region

NCD3Gaa 495–546UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 561–813UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 2

HGNC Alias Symbols

GPRC1B; mGlu2; MGLUR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000839.5

p.C234S

c.701G>C

Surrounding Variants

1 paper

NM_000839.5

p.C234S

c.700T>A

1 paper

NM_000839.5

p.N232T

c.695A>C

1 paper

NM_000839.5

p.R229C

c.685C>T

1 paper

NM_000839.5

p.A228T

c.682G>A

1 paper

NM_000839.5

p.M245L

c.733A>T

1 paper

NM_000839.5

p.A248T

c.742G>A

1 paper

NM_000839.5

p.A248V

c.743C>T

1 paper

NM_000839.5

p.G214S

c.640G>A

2 papers

NM_000839.5

p.R255*

c.763C>T

1 paper

NM_000839.5

p.A211A

c.633G>C

1 paper

NM_000839.5

p.A211V

c.632C>T

1 paper

NM_000839.5

p.V210E

c.629T>A