Varaico: Literature-Extracted Genetic Variants

GRM2

124 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 60–460UCSCReceptor family ligand binding region

NCD3Gaa 495–546UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 561–813UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 2

HGNC Alias Symbols

GPRC1B; mGlu2; MGLUR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000839.5

p.D295A

c.884A>C

Surrounding Variants

1 paper

NM_000839.5

p.A293T

c.877G>A

1 paper

NM_000839.5

p.N286T

c.857A>C

1 paper

NM_000839.5

p.E277E

c.831G>A

1 paper

NM_000839.5

p.E277K

c.829G>A

3 papers

NM_000839.5

p.I315V

c.943A>G

1 paper

NM_000839.5

p.S272A

c.814T>G

1 paper

NM_000839.5

p.L268P

c.803T>C

1 paper

NM_000839.5

p.R264C

c.790C>T

1 paper

NM_000839.5

p.D335E

c.1005C>A

1 paper

NM_000839.5

p.D335E

c.1005C>G

2 papers

NM_000839.5

p.R255*

c.763C>T

1 paper

NM_000839.5

p.R341W

c.1021C>T