Varaico: Literature-Extracted Genetic Variants

GRM2

124 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 60–460UCSCReceptor family ligand binding region

NCD3Gaa 495–546UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 561–813UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 2

HGNC Alias Symbols

GPRC1B; mGlu2; MGLUR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000839.5

p.K377N

c.1131G>C

Surrounding Variants

1 paper

NM_000839.5

p.K377N

c.1131G>T

1 paper

NM_000839.5

p.S366T

c.1096T>A

1 paper

NM_000839.5

p.R397C

c.1189C>T

1 paper

NM_000839.5

p.R358Q

c.1073G>A

2 papers

NM_000839.5

p.R346H

c.1037G>A

1 paper

NM_000839.5

p.R411W

c.1231C>T

1 paper

NM_000839.5

p.P343insFs

c.1027_1028insA

1 paper

NM_000839.5

p.R341W

c.1021C>T

1 paper

NM_000839.5

p.R417H

c.1250G>A

1 paper

NM_000839.5

p.D335E

c.1005C>A

1 paper

NM_000839.5

p.D335E

c.1005C>G

3 papers

NM_000839.5

p.I315V

c.943A>G