Varaico: Literature-Extracted Genetic Variants

GRM2

124 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 60–460UCSCReceptor family ligand binding region

NCD3Gaa 495–546UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 561–813UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 2

HGNC Alias Symbols

GPRC1B; mGlu2; MGLUR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000839.5

p.E516K

c.1546G>A

Surrounding Variants

1 paper

NM_000839.5

p.C522Y

c.1565G>A

1 paper

NM_000839.5

p.P524S

c.1570C>T

2 papers

NM_000839.5

p.A497T

c.1489G>A

1 paper

NM_000839.5

p.P496A

c.1486C>G

1 paper

NM_000839.5

p.P490P

c.1470C>G

1 paper

NM_000839.5

p.P546P

c.1638C>A

1 paper

NM_000839.5

p.D481N

c.1441G>A

1 paper

NM_000839.5

p.E555A

c.1664A>C

1 paper

NM_000839.5

p.Q558fs

c.1672_1673fs

1 paper

NM_000839.5

p.R467C

c.1399C>T

1 paper

NM_000839.5

p.R465L

c.1394G>T

1 paper

NM_000839.5

p.G464R

c.1390G>A