Varaico: Literature-Extracted Genetic Variants

GRM2

124 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 60–460UCSCReceptor family ligand binding region

NCD3Gaa 495–546UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 561–813UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 2

HGNC Alias Symbols

GPRC1B; mGlu2; MGLUR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000839.5

p.S601A

c.1801T>G

Surrounding Variants

1 paper

NM_000839.5

p.C616S

c.1846T>A

1 paper

NM_000839.5

p.C616S

c.1847G>C

1 paper

NM_000839.5

p.Y617F

c.1850A>T

1 paper

NM_000839.5

p.F584I

c.1750T>A

1 paper

NM_000839.5

p.L583L

c.1749C>G

1 paper

NM_000839.5

p.T620A

c.1858A>G

1 paper

NM_000839.5

p.R635W

c.1903C>T

1 paper

NM_000839.5

p.L637F

c.1909C>T

1 paper

NM_000839.5

p.A642S

c.1924G>T

1 paper

NM_000839.5

p.Q558fs

c.1672_1673fs

1 paper

NM_000839.5

p.S644A

c.1930T>G

1 paper

NM_000839.5

p.E555A

c.1664A>C