Varaico: Literature-Extracted Genetic Variants

GRM2

124 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 60–460UCSCReceptor family ligand binding region

NCD3Gaa 495–546UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 561–813UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 2

HGNC Alias Symbols

GPRC1B; mGlu2; MGLUR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000839.5

p.A733T

c.2197G>A

Surrounding Variants

1 paper

NM_000839.5

p.Y734C

c.2201A>G

1 paper

NM_000839.5

p.N735D

c.2203A>G

2 papers

NM_000839.5

p.S731A

c.2191T>G

1 paper

NM_000839.5

p.V736A

c.2207T>C

1 paper

NM_000839.5

p.S727C

c.2179A>T

1 paper

NM_000839.5

p.A726insFs

c.2176_2177insA

1 paper

NM_000839.5

p.A726S

c.2176G>T

1 paper

NM_000839.5

p.H723H

c.2169C>T

1 paper

NM_000839.5

p.K748N

c.2244G>C

1 paper

NM_000839.5

p.K748N

c.2244G>T

1 paper

NM_000839.5

p.E712A

c.2135A>C

1 paper

NM_000839.5

p.E712K

c.2134G>A