Varaico: Literature-Extracted Genetic Variants

GRM3

337 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 67–474UCSCReceptor family ligand binding region

NCD3Gaa 504–555UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 570–822UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 3

HGNC Alias Symbols

GPRC1C; mGlu3; MGLUR3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000840.3

p.P46S

c.136C>T

Surrounding Variants

1 paper

NM_000840.3

p.P46L

c.137C>T

3 papers

NM_000840.3

p.I47V

c.139A>G

3 papers

NM_000840.3

p.E49K

c.145G>A

2 papers

NM_000840.3

p.K50delFs

c.150delA

2 papers

NM_000840.3

p.G51fs

c.151_152fs

1 paper

NM_000840.3

p.G53R

c.157G>A

1 paper

NM_000840.3

p.G53R

c.157G>C

1 paper

NM_000840.3

p.G53E

c.158G>A

1 paper

NM_000840.3

p.G37D

c.110G>A

1 paper

NM_000840.3

p.G37V

c.110G>T

1 paper

NM_000840.3

p.E55K

c.163G>A

1 paper

NM_000840.3

p.E36*

c.106G>T