Varaico: Literature-Extracted Genetic Variants

GRM3

337 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 67–474UCSCReceptor family ligand binding region

NCD3Gaa 504–555UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 570–822UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 3

HGNC Alias Symbols

GPRC1C; mGlu3; MGLUR3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000840.3

p.V372I

c.1114G>A

Surrounding Variants

1 paper

NM_000840.3

p.R371H

c.1112G>A

1 paper

NM_000840.3

p.D374H

c.1120G>C

1 paper

NM_000840.3

p.R367H

c.1100G>A

1 paper

NM_000840.3

p.R367C

c.1099C>T

1 paper

NM_000840.3

p.Q360K

c.1078C>A

2 papers

NM_000840.3

p.Q360*

c.1078C>T

1 paper

NM_000840.3

p.Y384Y

c.1152C>T

1 paper

NM_000840.3

p.E385K

c.1153G>A

1 paper

NM_000840.3

p.K358T

c.1073A>C

1 paper

NM_000840.3

p.E387Q

c.1159G>C

1 paper

NM_000840.3

p.W355L

c.1064G>T

1 paper

NM_000840.3

p.F354_W355ins1

c.1062_1063insAGT