Varaico: Literature-Extracted Genetic Variants

GRM3

337 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 67–474UCSCReceptor family ligand binding region

NCD3Gaa 504–555UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 570–822UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 3

HGNC Alias Symbols

GPRC1C; mGlu3; MGLUR3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000840.3

p.D420N

c.1258G>A

Surrounding Variants

1 paper

NM_000840.3

p.D420Y

c.1258G>T

2 papers

NM_000840.3

p.M422I

c.1266G>A

2 papers

NM_000840.3

p.M422I

c.1266G>C

2 papers

NM_000840.3

p.M422I

c.1266G>T

1 paper

NM_000840.3

p.K423E

c.1267A>G

1 paper

NM_000840.3

p.K417fs

c.1249_1250fs

1 paper

NM_000840.3

p.K423T

c.1268A>C

1 paper

NM_000840.3

p.T416ins5

c.1247_1248ins15

1 paper

NM_000840.3

p.T416_K417ins10

c.1246_1250ins30

1 paper

NM_000840.3

p.I424V

c.1270A>G

1 paper

NM_000840.3

p.L411I

c.1231C>A

1 paper

NM_000840.3

p.R409C

c.1225C>T