Varaico: Literature-Extracted Genetic Variants

GRM5

270 papers

RefSeq Summary

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second...

Pfam Domains

ANF_receptoraa 67–474UCSCReceptor family ligand binding region

NCD3Gaa 506–558UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 573–821UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1162–1212UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 5

HGNC Alias Symbols

MGLUR5; GPRC1E; mGlu5; PPP1R86

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001143831.3

p.Y792C

c.2375A>G

Surrounding Variants

1 paper

NM_001143831.3

p.F793F

c.2379T>C

1 paper

NM_001143831.3

p.I800S

c.2399T>G

1 paper

NM_001143831.3

p.T780M

c.2339C>T

3 papers

NM_001143831.3

p.T780A

c.2338A>G

1 paper

NM_001143831.3

p.Y779C

c.2336A>G

1 paper

NM_001143831.3

p.A810T

c.2428G>A

1 paper

NM_001143831.3

p.E770A

c.2309A>C

1 paper

NM_001143831.3

p.A813_L814del2

c.2437_2441del6

1 paper

NM_001143831.3

p.G815G

c.2445C>A

1 paper

NM_001143831.3

p.P765S

c.2293C>T

1 paper

NM_001143831.3

p.V764F

c.2290G>T

1 paper

NM_001143831.3

p.P820P

c.2460G>A