Varaico: Literature-Extracted Genetic Variants

GRM5

270 papers

RefSeq Summary

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second...

Pfam Domains

ANF_receptoraa 67–474UCSCReceptor family ligand binding region

NCD3Gaa 506–558UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 573–821UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1162–1212UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 5

HGNC Alias Symbols

MGLUR5; GPRC1E; mGlu5; PPP1R86

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001143831.3

p.F277L

c.831C>G

Surrounding Variants

1 paper

NM_001143831.3

p.A275P

c.823G>C

1 paper

NM_001143831.3

p.T282M

c.845C>T

1 paper

NM_001143831.3

p.T282T

c.846G>A

1 paper

NM_001143831.3

p.A271_R272delFs

c.813_814delGG

3 papers

NM_001143831.3

p.K270R

c.809A>G

1 paper

NM_001143831.3

p.L286V

c.856C>G

1 paper

NM_001143831.3

p.L287L

c.861G>C

2 papers

NM_001143831.3

p.S266T

c.797G>C

1 paper

NM_001143831.3

p.S266N

c.797G>A

1 paper

NM_001143831.3

p.R292C

c.874C>T

1 paper

NM_001143831.3

p.K262R

c.785A>G

1 paper

NM_001143831.3

p.L260Q

c.779T>A