Varaico: Literature-Extracted Genetic Variants

GRM5

270 papers

RefSeq Summary

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second...

Pfam Domains

ANF_receptoraa 67–474UCSCReceptor family ligand binding region

NCD3Gaa 506–558UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 573–821UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1162–1212UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 5

HGNC Alias Symbols

MGLUR5; GPRC1E; mGlu5; PPP1R86

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001143831.3

p.N160S

c.479A>G

Surrounding Variants

1 paper

NM_001143831.3

p.S153F

c.458C>T

1 paper

NM_001143831.3

p.S153A

c.457T>G

1 paper

NM_001143831.3

p.S151A

c.451T>G

1 paper

NM_001143831.3

p.G150S

c.448G>A

1 paper

NM_001143831.3

p.V146D

c.437T>A

2 papers

NM_001143831.3

p.T175A

c.523A>G

1 paper

NM_001143831.3

p.S176I

c.527G>T

1 paper

NM_001143831.3

p.P142L

c.425C>T

2 papers

NM_001143831.3

p.R138H

c.413G>A

1 paper

NM_001143831.3

p.R138C

c.412C>T

1 paper

NM_001143831.3

p.F137fs

c.409_410fs

1 paper

NM_001143831.3

p.F137delFs

c.410delA