Varaico: Literature-Extracted Genetic Variants

GRM5

270 papers

RefSeq Summary

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second...

Pfam Domains

ANF_receptoraa 67–474UCSCReceptor family ligand binding region

NCD3Gaa 506–558UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 573–821UCSC7 transmembrane sweet-taste receptor of 3 GCPR

GluR_Homer-bdgaa 1162–1212UCSCHomer-binding domain of metabotropic glutamate receptor

Gene Aliases

HGNC Name

glutamate metabotropic receptor 5

HGNC Alias Symbols

MGLUR5; GPRC1E; mGlu5; PPP1R86

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001143831.3

p.I66I

c.198T>A

Surrounding Variants

1 paper

NM_001143831.3

p.A71T

c.211G>A

1 paper

NM_001143831.3

p.R61H

c.182G>A

1 paper

NM_001143831.3

p.R61C

c.181C>T

1 paper

NM_001143831.3

p.A59V

c.176C>T

2 papers

NM_001143831.3

p.A59E

c.176C>A

1 paper

NM_001143831.3

p.G58R

c.172G>C

1 paper

NM_001143831.3

p.G58R

c.172G>A

1 paper

NM_001143831.3

p.E77*

c.229G>T

1 paper

NM_001143831.3

p.N80I

c.239A>T

1 paper

NM_001143831.3

p.N80K

c.240T>G

1 paper

NM_001143831.3

p.N80K

c.240T>A

1 paper

NM_001143831.3

p.S81L

c.242C>T