Varaico: Literature-Extracted Genetic Variants

GRM6

254 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 67–478UCSCReceptor family ligand binding region

NCD3Gaa 513–564UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 579–839UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 6

HGNC Alias Symbols

GPRC1F; mGlu6; MGLUR6; CSNB1B

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000843.4

p.P688delFs

c.2062delG

Surrounding Variants

1 paper

NM_000843.4

p.P689fs

c.2065_2066fs

2 papers

NM_000843.4

p.S685W

c.2054C>G

1 paper

NM_000843.4

p.P694R

c.2081C>G

1 paper

NM_000843.4

p.R684H

c.2051G>A

1 paper

NM_000843.4

p.T695A

c.2083A>G

2 papers

NM_000843.4

p.R684C

c.2050C>T

1 paper

NM_000843.4

p.Q697*

c.2089C>T

4 papers

NM_000843.4

p.Q697L

c.2090A>T

5 papers

NM_000843.4

p.L698V

c.2092C>G

1 paper

NM_000843.4

p.I700V

c.2098A>G

1 paper

NM_000843.4

p.Q697_V699del3

c.2089_2096del9

5 papers

NM_000843.4

p.R677H

c.2030G>A