Varaico: Literature-Extracted Genetic Variants

GRM6

254 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 67–478UCSCReceptor family ligand binding region

NCD3Gaa 513–564UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 579–839UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 6

HGNC Alias Symbols

GPRC1F; mGlu6; MGLUR6; CSNB1B

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000843.4

p.E644D

c.1932G>T

Surrounding Variants

1 paper

NM_000843.4

p.E644D

c.1932G>C

2 papers

NM_000843.4

p.P645R

c.1934C>G

1 paper

NM_000843.4

p.V642A

c.1925T>C

1 paper

NM_000843.4

p.A651A

c.1953C>T

3 papers

NM_000843.4

p.R653C

c.1957C>T

1 paper

NM_000843.4

p.R653H

c.1958G>A

1 paper

NM_000843.4

p.R653delFs

c.1957_1958delCG

1 paper

NM_000843.4

p.G630V

c.1889G>T

1 paper

NM_000843.4

p.Y625Y

c.1875C>T

1 paper

NM_000843.4

p.R621Q

c.1862G>A

1 paper

NM_000843.4

p.L668P

c.2003T>C

15 papers

NM_000843.4

p.R621*

c.1861C>T